High-sensitivity C-reactive protein in HIV care: Tuberculosis diagnosis and short-term mortality in a cohort of Kenyan HIV patients in the DREAM programme

ObjectiveTuberculosis (TB) is the leading cause of death in HIV-positive people. In Kenya, 140 000 new TB cases occurred 2019, and 13 patients died due to TB. The objective this study was investigate role high-sensitivity C-reactive protein (HS-CRP) diagnosis prediction mortality patients.MethodsThe IDEA-TB Study enrolled adult attending three DREAM centres Kenya who were suspected having A lateral flow urine lipoarabinomannan assay (LF-LAM), serum HS-CRP, GeneXpert MTB/RIF (Xpert MTB/RIF) performed. Six-month survival evaluated.ResultsA total 574 enrolled. median (interquartile range) age, body mass index, CD4 count 45 years (37–54 years), 20.5 kg/m2 (18.5–23.69 kg/m2), 477 cells/mL (290–700 cells/mL), respectively. confirmed 87 (15.2%) patients. Concordance between Xpert LF-LAM tests 87.1%. HS-CRP higher (35.39 mg/l vs 9.21 mg/l). Malnutrition elevated associated with TB: odds ratio (OR) 2.5 (95% confidence interval (CI) 1.14–5.72) OR 6.6 CI 3.87–11.52), Nine (1.6%) during follow-up. No single factor mortality. Only combination malnutrition highly predictive (odds 9.8, 95% 1.88–50.95); association stronger (33.3% 1.0%; 47.6, 7.03–322.23).ConclusionTB remains challenging. could play a predicting early symptomatic